Whilst reduced-count MBL rarely progresses to CLL, large-rely MBL progresses to CLL demanding therapy in a fee of one% to 2% per year. Superior-depend MBL is distinguished from Rai 0 CLL according to if the B-mobile depend is above or underneath 5 × 109/L. Although individuals with both equally substantial-rely MBL and CLL Rai phase 0 are at great